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17BULLETIN 21Worldwide LocationsHEADQUARTERS USANoveon, Inc.9911 Brecksville RoadCleveland, Ohio 44141-3247Phone: 800.379.5389216.447.5000Fax: 216.447.5740EUROPENoveon PharmaP.O. Box 115183060 Raublin16BULLETIN 2121.9 SummaryThe data in this bulletin, along with the previous data presented in Technical Bulletin20, shows that Carbopol?71G NF is a useful and versatile controlled-releaseadditive for 15BULLETIN 21In these formulations, Carbopol?71G NF is practically equivalent to Carbopol 971PNF in controlling the release of Ketoprofen.Ketoprofen Wet Granulation SIF0204060801001200 100 200 300 40014BULLETIN 2121.8 Comparison of Carbopol?71G NF to 971P NF in Wet Granulationof KetoprofenIdentical formulations were made up, changing only the controlled-release additive –Carbopol 71G NF for 971P N13BULLETIN 21USP Test 221.7 Carbopol?71G NF Has Similar Effectiveness at Controlling theRelease of Theophylline & Acetaminophen in Direct CompressionTheophylline Extended Release - USP Test 2-G8D-10%,12BULLETIN 2121.6 Direct Compression Theophylline Tablets – Effect of Carbopol?71G NF LevelFormulations were prepared with the same ingredients from 10% to 25%Carbopol 71G NF, changing it out with Emc11BULLETIN 2121.5 Direct Compression Acetaminophen – Lot-to-Lot ReproducibilityThe formulation immediately above was prepared with 24% of two lots of Carbopol?71G NF. There was no statistical differe10BULLETIN 2121.4 Direct Compression Acetaminophen – Effect of Carbopol?71G NF LevelThe study below shows the effects of varying Carbopol 71G NF level on tabletproperties and dissolution performance.F